黄学石

发布者:系统管理员发布时间:2013-07-27浏览次数:18788

黄学石,现任东北大学生命科学与健康学院微生物药物研究所所长,教授,博士生导师。1997年于北京医科大学获得药学学士学位;2002年于中国协和医科大学获博士学位,同年赴德国Hans Knoell研究所从事微生物药物研究工作。2005年作为人才引进回国就职于中国医科大学,2012年7月调入东北大学工作。迄今为止获得多项国家和省部级课题资助;在国际期刊《Angew. Chem. Int. Ed.》、《Org. Biomol. Chem.》、《J. Med. Chem.》、《J. Nat. Prod.》等杂志发表SCI论文30余篇。

 

科研方向:

  1.微生物活性代谢产物研究

  2.传统中药活性物质基础研究

  3.活性天然产物结构修饰与构效关系研究

 

代表性论文

1.Liya Li, Jialin Xu, Yu Mu, Li Han, Ruohan Liu, Yaping Cai, Xueshi Huang.* Chemical Characterization and Anti-hyperglycaemic Effects of Polyphenol Enriched Longan (Dimocarpus longan Lour.) Pericarp Extracts. J Funct. Foods, 2015, 13, 314-322.

2.Li Han, Chun Gao, Yi Jiang, Peipei Guan, Jiang Liu, Liya Li, Lihua Xu, Xueshi Huang.* Jiangrines A−F and Jiangolide from an Actinobacterium, Jiangella gansuensis. J. Nat. Prod., 2014, 77, 2605−2610.

3.Yiqing Li*, Li Han, He Rong, Liya Li, Lixing Zhao, Longxia Wu, Lihua Xu, Yi Jiang and Xueshi Huang.* Diastaphenazine, a new dimeric phenazine from an endophytic Streptomyces diastaticus subsp. Ardesiacus. J. Antibiot., (17 September 2014) doi:10.1038/ja.2014.124.

4.Li Han, Peiyuan Huo, Huahong Chen, Songtao Li, Yi Jiang, Liya Li, Lihua Xu, Chenglin Jiang, Xueshi Huang.* New Derivatives of Nonactic and Homononactic Acids from Bacillus pumilus Derived from Breynia fruticosa. Chemistry & Biodiversity, 2014, 11, 1088-1098.

5.Zhao M, Zhao J, He G, Sun X, Huang X*, Hao L*. Effects of astragaloside IV on action potentials and ionic currents in guinea-pig ventricular myocytes. Biological & Pharmaceutical Bulletin, 2013, 36(4), 515-521.

6.Zhang J, Jiang Y, Cao Y, Liu J, Zheng D, Chen X, Han L, Jiang C, Huang X.* Violapyrones A-G, α-Pyrone Derivatives from Streptomyces violascens Isolated from Hylobates hoolock Feces. J. Nat. Prod., 2013, 76(11), 2126-2130.

7.Zheng D, Han L, Jiang Y, Cao YR, Liu J, Chen X, Li YQ, Huang XS.* Structure elucidation of four prenylindole derivatives from Streptomyces sp. isolated from Ailuropoda melanoleuca feces. Magn. Reson. Chem. 2013, 51(3), 188-191.

8.Zheng D, Han L, Li Y, Li J, Rong H, Leng Q, Jiang Y, Zhao L, Huang X.* Isostreptazolin and sannaphenol, two new metabolites from Streptomyces sannanensis. Molecules, 2012, 17(1), 836-842.

9.S. Li, L. Han, J. Liu, Y. Hu, D. Zheng, Y. Fu, X. Huang.* Synthesis of seco-chlorinated derivatives of phenanthroindolizidine precursors via Friedel-Crafts reaction. Molecules, 2010, 15, 8501-8506.

10.S. Li, L. Han, L. Sun, D. Zheng, J. Liu, Y. Fu, X. Huang*, Z. Wang. Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids. Molecules, 2009, 14, 5042-5053.

11.Li YQ§, Huang XS§(同等贡献), Ishida K, Maier A, Kelter G, Jiang Y, Peschel G, Menzel KD, Li MG, Wen ML, Xu LH, Grabley S, Fiebig HH, Jiang CL, Hertweck C, Sattler I. Plasticity in gilvocarcin-type C-glycoside pathways: discovery and antitumoral evaluation of polycarcin V from Streptomyces polyformus. Organic & Biomolecular Chemistry, 2008, 6(19), 3601-3605.

12.Huang X, He J, Niu X, Menzel KD, Dahse HM, Grabley S, Fiedler HP, Sattler I, Hertweck C. Benzopyrenomycin, a cytotoxic bacterial polyketide metabolite with a benzo[a]pyrene-type carbocyclic ring system. Angew. Chem. Int. Edit., 2008, 47(21), 3995-3998.

13.Huang X, Roemer E, Sattler I, Moellmann U, Christner A, Grabley S. Lydiamycins A-D: cyclodepsipetides with antimycobacterial properties, Angew. Chem. Int. Edit., 2006, 45(19), 3067-3072.

 

联系方式

地址:沈阳市东陵区智慧大街500号,东北大学生命科学与健康学院微生物药物研究所

邮编:110169

E-mail: huangxs@mail.neu.edu.cn 

办公电话:024-83656106