范永强
博士，教授，博士生导师
东北大学海外百人青年特聘教授
教育和工作经历:
2002-2006大连理工大学生物工程专业，学士
2006-2012大连理工大学环境科学与生命学院生物化工专业，博士
2013-2018德克萨斯州立大学休斯顿健康中心，博士后
2018-至今 东北大学生命科学与健康学院；沈阳材料科学国家研究中心，教授，博士生导师
主要研究方向:
本人在美国进行博士后工作期间主要从事蛋白质错误翻译对微生物生理生化影响的分子机制研究。目前的研究方向主要为两个方面：（1）微生物金属腐蚀的分子机制研究。利用分子生物学、基因组学、转录组学、蛋白质组学、代谢组学以及宏基因组学等相关技术，主要研究铜绿假单胞菌、硫酸盐还原菌、地杆菌、海洋弧菌等常见腐蚀导电微生物腐蚀金属材料的分子机制，同时针对海洋等实际环境，对其中的腐蚀性微生物进行针对性研究；（2）功能性生物被膜材料的研究。利用合成生物学技术，结合3D打印技术，与材料科学交叉融合，以大肠杆菌、弧菌以及枯草芽孢杆菌为底盘，针对性金属的腐蚀防护，设计与构建功能性生物被膜材料。
科研项目:
(1). 国家重点研发计划，项目编号2020YFA0907300，《高效生物产氢体系的设计组装》，2020.11-2025.11，项目/课题骨干，获资助金额92万元，在研；
(2). 东北大学“海外百人”引进人才启动经费，项目编号01270021920501*054，2018.09-2023.08，主持，资助金额200万，在研；
(3). 中央高校基本科研业务费优秀青年培育项目,项目编号N2120007, 《蛋白质错误翻译对细菌金属腐蚀的影响及其分子机制》 2021.01-2023.12, 主持，资助金额30万，在研；
(4). 中央高校基本科研业务费交叉融合项目,项目编号N2002019, 《金属材料微生物腐蚀机理与监检测》 2020.01-2022.12, 项目骨干，资助金额40万，在研；
(5). 中央高校基本科研业务费青年教师科研创新项目,项目编号N182004003, 《蛋白质错误翻译对病原细菌毒性及其与宿主互作的影响和机制》 2019.01-2020.12, 主持，资助金额13万，结题；
(6). 中央高校基本科研业务费引进人才启动项目,项目编号N172410002-17, 《蛋白质错误翻译对细菌耐药性的影响及其机制》 2018.01-2018.12, 主持，资助金额20万，结题；
代表性论文:
1. Hong Zhanga, Zhihui Lyua, Yongqiang Fan, Christopher R. Evansb, Karl W. Barber, Kinshuk Banerjeeg, Oleg A. Igoshin, Jesse Rineharte, Jiqiang Ling. (2020). Metabolic stress promotes stop-codon readthrough and phenotypic heterogeneity. PNAS. 117(36): 22167-22172. (co-first author, IF=9.412)
2. Christopher R. Evans, Yongqiang Fan, Jiqiang Ling. (2019). Increased mistranslation protects E. coli from protein misfolding stress due to activation of a RpoS-dependent heat shock response. FEBS Letters. 593: 3220-3227. (co-first author, IF=3.057)
3. Yongqiang Fan, Laurel Thompson, Zhihui lyu, Todd A. Cameron, Nicholas R.De Lay, Anne Marie Krachler, Jiqiang Ling. (2019). Optimal translational fidelity is critical for Salmonella virulence and host interactions. Nucleic Acids Research. 47(10): 5356-5367. (IF=11.501)
4. Yongqiang Fan, Christopher R. Evans, Kalyn J. Weiss, Jiqiang Ling. (2018).Errors during Gene Expression: Single-Cell Heterogeneity, Stress Resistance, and Microbial-Host Interactions. mBio. 9(4): pii: e01018-18. (IF=6.748)
5. Yongqiang Fan, Christopher R. Evans, Karl W. Barber, Kinshuk Banerjee, Kalyn J. Weiss, William Margolin, Oleg A. Igoshin, Jesse Rinehart, Jiqiang Ling. (2017). Heterogeneity of Stop Codon Readthrough in Single Baterial Cells and Implications for Population Fitness. Molecular Cell.67(5):826-836. (IF=15.548)
6. Yongqiang Fan, Christopher R. Evans, Jiqiang Ling. (2017). Rewiring protein
synthesis: From natural to synthetic amino acids. Biochimica et Biophysica Acta
(BBA) - General Subjects, 01.014. (IF=3.422)
7. Yongqiang Fan, Christopher R. Evans, Jiqiang Ling. (2016). Reduced protein synthesis fidelity inhibits flagellar biosynthesis and motility. Scientific Report, 6, 30960. (IF=3.998)
8. Yongqiang Fan, Jiang Wu, Matthew H. Ung, Nicholas De Lay, Chao Cheng and JiqiangLing. (2015). Protein mistranslation protects bacteria against oxidative stress. Nucleic Acids Research, 43(3):1740-1748. (IF=11.501)
9. Jiang Wu, Yongqiang Fan, Jiqiang Ling. (2014). Mechanism of oxidant-induced mistranslation by threonyl-tRNA synthetase. Nucleic Acids Research, 42(10):6523-6531. (IF=11.501)
10. Yongqiang Fan, Hongjian Liu, Li Yan, Yushi Luan, JunMo Yang, Haimeng Zhou, Yulong Wang. (2013). Optimized transformation of Streptomyce sp. ATCC 39366 producing leptomycin by electroporation. The Journal of Microbiology, 51(3):318-22.
11. Yongqiang Fan, Hongjian Liu, Chang Li, Yushi Luan, JunMo Yang, Yulong Wang. (2013). Inactivation of recombinant human brain-type creatine kinase during denaturation by guanidine hydrochloride in a macromolecular crowding system. Applied Biochemistry and Biotechnology, 169(1): 268-280.
12. Yongqiang Fan, Jinhyuk Lee, Sangho Oh, Hongjian Liu, Chang Li, Yushi Luan, JunMo Yang, Haimeng Zhou, ZhirongLü, Yulong Wang. (2012). Effects of osmolytes on human brain-type creatine kinase folding in dilute solutions and crowding systems. International Journal of Biological Macromolecules, 51(5): 845-858.
13. Yongqiang Fan, Hongjian Liu, Chang Li, Yushi Luan, JunMo Yang, Yulong Wang. (2012). Effects of macromolecular crowding on refolding of recombinant human brain-type creatine kinase. International Journal of Biological Macromolecules, 51(1-2): 113-118.
14. Yongqiang Fan, Yushi Luan, Lijia An, Kun Yu. (2008). Arbuscular mycorrhizae formed by Penicillium pinophilum improve the growth, nutrient uptake and photosynthesis of strawberry with two inoculum-types. Biotechnol. Lett., 30(8): 1489-1494.
招聘信息:
本课题组长期招聘博士后、讲师和副教授，欢迎具有微生物学、分子生物学以及生物信息学背景的有志之士的加入！
联系方式:
地址：沈阳市浑南区创新路195号，东北大学生命科学与健康学院生科楼A304-A
邮编：110169
电话：+024-83656108
Email: fanyongqiang@mail.neu.edu.cn