许家林，博士，东北大学生命科学与健康学院生化与分子生物学研究所教授，博士研究生导师。2009年毕业于北京协和医学院生物化学与分子生物学专业，并获理学博士学位。从2009年11月起，在美国罗德岛大学药学院（University of Rhode Island）从事博士后研究。2013年8月进入东北大学生命科学与健康学院任职。先后主持和参与国家自然科学基金面上项目、国家自然科学基金主任基金项目和中央高校基本科研业务费等科研项目7项，在Diabetes、International Journal of Biological Sciences、Obesity、Journal of Lipid Research和Molecular Nutrition & Food Research等杂志发表SCI论文三十余篇。
教育经历
2005.09-2009.07 北京协和医学院生物化学与分子生物学专业理学博士
2001.09-2004.07 上海体育学院运动人体科学系运动生理学专业教育学硕士
1994.09-1998.07 安徽师范大学生物系生物教育专业理学学士
学术兼职
辽宁省卫生毒理专业委员会委员，中国信息协会医疗卫生和健康产业分会体医融合和健康产业学组委员，辽宁省细胞生物学学会先进医工融合技术专业委员会理事，中国生物化学与分子生物学学会会员。
科研方向
通过使用多种转基因小鼠动物模型和细胞模型，探索肥胖发生和糖尿病发展的致病机理；通过研究多种天然化合物对糖尿病和肥胖等疾病病症的影响，寻求可以有效抑制肥胖和糖尿病发生和发展的先导化合物；研究肝脏再生的调控机理，进一步探索非酒精性脂肪肝对肝细胞增殖和分化的影响及分子机制。
主持及参与基金项目：
1．国家自然科学基金面上项目：BAP31调节脂肪组织堆积和肥胖发生的作用研究（项目批准号：81974120）。55万元，项目主持者。
2．国家自然科学基金面上项目：BAP31在非酒精性脂肪肝和糖代谢中的作用研究（项目批准号：81570788）。58万元，项目主持者。
3．国家自然科学基金主任基金：Nrf2对高脂饮食诱导肥胖引起的免疫紊乱的调节机制的探讨（项目批准号：81341102）。15万元，项目主持者。
4．中央高校基本科研业务费探索导向重点项目：PTP-PEP对肥胖诱导的免疫紊乱的调节机制的探讨。40万元，项目主持者。
5．中央高校基本科研业务费青年教师科研创新基金项目：BAP31基因敲除诱导SREBP1C激活并促进非酒精性脂肪肝形成。10万元，项目主持者。
6．国家自然科学基金面上项目：BAP31胞内抗体经外泌体microRNA抑制胃癌转移的作用及机制研究（项目批准号：31972898），52万元。第二完成人。
7．国家自然科学基金面上项目：BAP31在小鼠中的功能解析（项目批准号：31370784），88万元。第二完成人。
代表性学术论文：
1. Xueying Wei, Liya Li, Jie Zhao, Yan Huo, Xiaodi Hu, Jingyi Lu, Jingbo Pi, Wei Zhang, Lisheng Xu, Yudong Yao, and Jialin Xu. BAP31 depletion inhibited adipogenesis, repressed lipolysis and promoted lipid droplets abnormal growth via attenuating Perilipin1 proteasomal degradation. International Journal of Biological Sciences. 2023, 19(6):1713-1730. (IF=10.750)
2. Guihua Wang, Jialin Xu, Hang Ma, Yu Mu, Wen Xu, Na Yan, Wei Liu, Dan Zheng, Xueshi Huang, Liya Li. Phenolipid JE improves metabolic profile and inhibits gluconeogenesis viamodulating AKT-mediated insulin signaling in STZ-induced diabetic mice. Pharmacological Research. 2023, 187, 106569. (IF=10.334)
3. Yuanyuan Li, Dongsong Bai, Yongming Lu, Jia Chen, Haoning Yang, Yu Mu, Jialin Xu, Xueshi Huang, Liya Li. The crude guava polysaccharides ameliorate high-fat diet-induced obesity in mice via reshaping gut microbiota. International Journal of Biological Macromolecules. 2022, 213:234-246. (IF=8.025)
4. Wen Xu, Jiaying Li, Jia Chen, Jialin Xu, Dan Zheng, Mengxia Wu, Yu Mu, Xueshi Huang, Liya Li. Discovery, preparation and characterization of lipid-lowering alkylphenol derivatives from Syzygium jambos fruit. Food Chemistry. 2022, 396, 133668. (IF=9.231)
5. Yan Huo, Xin Zhao, Jie Zhao, Xuewei Kong, Liya Li, Tao Yuan, Jialin Xu. Hypoglycemic effects of Fu-Pen-Zi (Rubus chingii Hu) fruit extracts in streptozotocin-induced type 1 diabetic mice. Journal of Functional Foods. 2021, 87, 104837. (IF=5.223)
6. Yuanyuan Li, Jialin Xu, Dongli Li, Hang Ma, Yu Mu, Dan Zheng, Xueshi Huang, and Liya Li. Chemical Characterization and Hepatoprotective Effects of a Standardized Triterpenoid-Enriched Guava Leaf Extract. Journal of Agricultural and Food Chemistry. 2021, 69:3626-3637. (IF=5.595)
7. Jie Zhao, Xiaotong Lv, Yan Huo, Xiaodi Hu, Xiaochen Li, Shizhuo Sun, Xin Zhao, Xuewei Kong and Jialin Xu. Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice. InternationalJournal of Molecular Sciences. 2021, 22, 10788. (IF=6.208)
8. Jialin Xu, Mingxi Li, Yi Zhang, Suo Chu, Yan Huo, Jie Zhao, and Chunpeng Wan. Huangjinya black tea alleviates obesity and insulin resistance via modulating fecal metabolome in high-fat diet-fed mice. Molecular Nutrition &Food Research. 2020, 64, 2000353. (IF=6.575)
9. Mingxi Li*, Jialin Xu*, Yi Zhang, Suo Chu, Shizhuo Sun, Yan Huo, Jie Zhao, Xiaodi Hu, Chunpeng Wan, Liya Li. Comparative analysis of fecal metabolite profiles in HFD-induced obese mice after oral administration of huangjinya green tea extract. Food and Chemical Toxicology. 2020, 145, 111744. (*Co-first author.IF=5.572)
10. Yuanyuan Li, Jialin Xu, Dongli Li, Hang Ma, Yu Mu, Xueshi Huang, and Liya Li. Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury via regulating Nrf2 and JNK signaling pathways. Food & Function. 2020, 11, 8297. (IF=6.317)
11. Jialin Xu, Tingting Liu, Yuanyuan Li, Wei Liu, Zhanjun Ding, Hang Ma,Navindra P. Seeram, Yu Mu, Xueshi Huang, and Liya Li. Jamun (Eugenia jambolana Lam.) Fruit Extract PreventsObesity by Modulating the Gut Microbiome inHigh-Fat-Diet-Fed Mice. Molecular Nutrition & Food Research. 2019, 63(9): e1801307. (IF=6.317)
12. Zhenhua Wu, Fan Yang, Shan Jiang, Xiaoyu Sun and Jialin Xu. Induction of Liver Steatosis in BAP31-Deficient MiceBurdened with Tunicamycin-Induced EndoplasmicReticulum Stress. InternationalJournal of Molecular Sciences. 2018, 19, 2291. (IF=6.208)
13. Jialin Xu, Tingting Liu, Yuanyuan Li, Chunhui Yuan, Hang Ma, Navindra P. Seeram, Feifei Liu, Yu Mu, Xueshi Huang and Liya Li. Hypoglycemic and hypolipidemic effects oftriterpenoid-enriched Jamun (Eugenia jambolanaLam.) fruit extract in streptozotocin-induced type1 diabetic mice. Food &Function. 2018, 9, 3330. (IF=6.317)
14. Jialin Xu, Chunhui Yuan, Guihua Wang,Jiaming Luo, Hang Ma, Li Xu, Yu Mu, Yuanyuan Li, Navindra P. Seeram, Xueshi Huang, and Liya Li. Urolithins Attenuate LPS-Induced Neuroinflammation inBV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways. Journal of Agricultural and Food Chemistry. 2018, 24; 66(3):571-580. (IF=5.595，2019年3月ESI高被引论文)
15. Jialin Xu,Liya Li,Yanqing Wang,Yaqi Li, Mu Shan, Shizhuo Sun, Yang Yu, Bing Wang. Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice. Journal of Lipid Research.2018, 59(1):35-47. (IF=6.676，封面文章)
16. Jialin Xu, Prajakta Shimpi, Laura Armstrong, Deanna Salter, Angela L. Slitt. PFOS induces adipogenesis and glucose uptake in association withactivation of Nrf2 signaling pathway. Toxicology and Applied Pharmacology. 2016, 290:21-30. (IF=6.676)
17. Jialin Xu,Ajay C. Donepudi, Vijay R. More, SupriyaR. Kulkarni, Liya Li, Liangran Guo, Bingfang Yan, ChatterjeeTapan, Weintraub Neal, and Angela L. Slitt. Deficiency in Nrf2 Transcription Factor Decreases Adipose TissueMass and Hepatic Lipid Accumulation in Leptin-Deficient Mice. Obesity. 2014, 23:335-344. (IF=9.298)
18. Jialin Xu, Supriya R. Kulkarni, Ajay C. Donepudi, Vijay R. More, and Angela L. Slitt. Enhanced Nrf2 Activity Worsens Insulin Resistance,Impairs Lipid Accumulation in Adipose Tissue, andIncreases Hepatic Steatosis in Leptin-Deficient Mice. Diabetes. 2012, 61:3208-3218.(IF=9.305)
19. Yao Song*, Jialin Xu*, Yanfeng Li, Chunshi Jia, Xiaowei Ma, Lei Zhang, Xiaojie Xie, Yong Zhang, Xiang Gao, Youyi Zhang, Dahai Zhu. Cardiac ankyrin repeat protein attenuates cardiac hypertrophy by inhibition of ERK1/2 and TGF-β signaling pathways. PlOS ONE. 2012, 7(12): e50436. (*Co-first author.IF=3.752)
20. 许家林，李艳凤，朱大海。心肌锚定重复序列蛋白基因心脏特异敲除小鼠模型构建与鉴定。基础医学与临床, 2011, 31(11):1217-1222。
联系方式
地址：辽宁省沈阳市浑南区创新路195号
东北大学生命科学与健康学院生化与分子生物学研究所
邮编：110819
电话：024-83656117
E-mail：Jialin_xu@mail.neu.edu.cn