I. 个人信息：
盛韧 博士
研究方向：细胞生物学、肿瘤生物学、化学生物学
联系方式：shengren@mail.neu.edu.cn; shengren1211@126.com
II. 教育及工作经历
2004.8-2008.7 吉林大学化学学院，化学学士
2008.8-2013.12 University of Illinois at Chicago, 化学博士
2014.1-2015.4 University of Illinois at Chicago, 博士后研究员 (with Dr. Wonhwa Cho)
2015.5-2018.7 Harvard Medical School/Boston Children’s Hospital, 博士后研究员 (with Dr. Xi He)
2018.8至今 东北大学生命科学与健康学院，教授、博士生导师、独立PI、课题组组长
III. 主要研究方向
1. As a classical morphogen signaling, Wnt/β-catenin pathway was well-known for decades as one of the central machineries in governing development and homeostasis, as well as a leading cause of human cancers. Despite the explicit understanding of the key components, discovery of novel regulators of Wnt signaling remains promisingly fruitful and meaningful. With the development in life science research, new theories and focuses emerged in the past few years. In the second half of the game on understanding Wnt, we aimed to bring in new players and to change new strategies, which were under-explored, to provide both novel mechanistic insights and therapeutic opportunities against Wnt-dysregulated diseases.
2. CDKL family protein kinase belong to CMGC superfamily kinase. Unlike the CDK and MAPK families, molecular and functional understanding of CDKL family is largely obscure. Most basic biological questions remain unanswered in this field. Our lab is interested in studying the roles of CDKL kinases in various biological processes and interrogating the underlying mechanism. We tend to employ animal and clinical models to illustrate the biological/pathological importance of CDKL kinases. Besides the basic biomedical interest, we are also active in developing small molecule inhibitors against CDKL kinases to potentially treat human diseases.
本课题组正积极招收相关领域博士、博士后，欢迎加盟！
IV. 学术任职与奖励
东北大学“海外百人计划”特聘教授
辽宁省第一届“兴辽英才计划”“青年拔尖人才”
中国健康管理协会理事
国家自然科学基金委员会生命学部、医学部函评专家
剑兰生物高等研究院高级顾问
广州Character生物药业首席科学官
V. 科研项目
东北大学“海外百人”资助，01270021920501，主持
教育部N16中央高校基本科研业务费，N161003001，主持
兴辽英才计划“青年拔尖人才”，XLYC1807239，主持
教育部N18中央高校基本科研专项资金资助，N182005006，主持
国家自然科学基金面上项目，31970721，主持
国家自然科学基金青年基金项目，81902830，主持
教育部N20科研创新项目，N2020008，主持
国家自然科学基金-国际(地区)合作与交流项目，C-0030，子课题负责人
VI. 代表性论文（按时间顺序）(#first; *corresponding)
1. USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential.
Wang Y#, Mao A#, Liu J#, Li P#, Zheng S, Tong T, Li Z, Zhang H, Ma L, Lin J, Pang Z, Han Q, Qi F, Zhang X, Chen M, He X, Zhang XJ, Fei T, Liu B, Gao D, Cao L*, Wang Q*, Li Y*, Sheng R*. Cell Chemical Biology, 2023 Aug 11;S2451-9456(23)00246-5.
2. Anti-pan-Rspo chimeric protein-conjugated albumin nanoparticle provides promising opportunities in cancer targeted therapy.
Zheng S#, Zhang X#, Pang Z, Liu J, Liu SY*, Sheng R*. Advanced Healthcare Materials, 2023 Jul 6;e2301441.
3. Aberrant cholesterol metabolism and Wnt/β-catenin signaling coalesce via Frizzled5 in supporting cancer growth.
Zheng S, Lin J, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang XJ, Zhao C, Qi J, Cao L, Wang M*, He X*, Sheng R*. Advanced Science, 2022 Oct;9(28):e2200750.
4. CDKL3 promotes osteosarcoma progression by activating Akt/PKB.
He A#*, Ma L#, Huang Y#, Zhang H, Duan W, Li Z, Fei T, Huang W, Wu H, Liu L, Yuan J, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R*, Xiang D*. Life Science Alliance, 2020 Mar 31;3(5).
5. Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol.
Liu SL#, Sheng R#, Jung JH, Wang L, Stec E, O’Connor MJ, Song S, Bikkavilli RK, Winn R, Lee D, Baek K, Ueda K, Levitan I, Kim KP, Cho W*. Nature Chemical Biology, 2017 Mar;13(3):268-274.
6. Lipids regulate Lck activity through their interactions with the Lck SH2 domain.
Sheng R#, Jung DJ#, Silkov A, Kim H, Wang ZG, Xin Y, Kim E, Park MJ, Thiagarajan-Rosenkranz P, Honig B, Beak K, Ryu S, Lorieau J, Kim YM*, Cho W*. Journal of Biological Chemistry, 2016 Aug 19;291(34):17639:50.
7. SH2 domains serve as lipid-binding modules for pTyr-Signaling proteins.
Park MJ#, Sheng R#, Silkov A#, Jung DJ, Wang ZG, Xin Y, Kim H, Thiagarajan-Rosenkranz P, Song S, Yoon Y, Nam W, Kim I, Kim E, Lee DG, Chen Y, Singaram I, Wang L, Jang MH, Hwang CS, Honig B, Ryu S, Lorieau J, Kim YM*, Cho W*. Highlighted by Cell (04/2016), Nature Review in Molecular Cell (05/2016), Cancer Discovery (04/2016) and F1000Prime (04/2016) Molecular Cell, 2016 Apr 7; 62(1): 7-20.
8. Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling.
Sheng R#, Kim H#, Lee H#, Xin Y, Chen Y, Tian W, Cui Y, Choi JC, Doh J, Han JK*, Cho W*. Nature Commununications, 2014; 5:4393.
9. Cholesterol modulates cell signaling and protein networking by specifically interacting with scaffold proteins.
Sheng R#, Chen Y#, Yung Gee H, Stec E, Melowic HR, Blatner NR, Tun MP, Kim Y, Källberg M, Fujiwara TK, Hye Hong J, Pyo Kim K, Lu H, Kusumi A, Goo Lee M, Cho W*. Nature Communications, 2012;3:1249.
10. Genome-wide identification and functional annotation of dual specificity protein- and lipid-binding modules that modulate protein interactions at the membrane.
Chen Y#, Sheng R#, Kallberg M#, R. Silkov A, Tun MP, Bhardwaj N, Kurilova S, Hall RA, Honig B, Lu H*, and Cho W*. Molecular Cell, 2012 Apr 27;46(2):226-37.
VI. 部分合作论文（按时间顺序）(#first; *corresponding)
1. Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface.
Li M#, Zheng J#, Luo D#, Xu K, Sheng R, MacDonald BT, He X, Zhang X*. EMBO Rep, 2023 Jun 5;24(6):e55873.
2. A cascade amplification strategy for ultrasensitive Salmonella typhimurium detection based on DNA walker coupling with CRISPR-Cas12a.
Zhang H,# Yao S#, Li J, Wang J, Li H, Fu Y, Sheng R, Zhang X*, Zhao C*. Journal of Colloid Interface Science, 2022 Nov;625:257-263.
3. Volumetric compression induces intracellular crowding to control intestinal organoid growth via Wnt/β-Catenin signaling.
Li Y#, Chen M#, Hu J, Sheng R, Lin Q, He X, Guo M*. Cell Stem Cell, 2021Jan 7;28(1):63-78.e7.
4. Raft-based interactions of gangliosides with a GPI-anchored receptor.
Komura N, Suzuki KG, Ando H, Konishi M, Koikeda M, Imamura A, Chadda R, Fujiwara TK, Tsuboi H, Sheng R, Cho W, Furukawa K, Furukawa K, Yamauchi Y, Ishida H, Kusumi A*, Kiso M*. Nature Chemical Biololgy, 2016 Jun;12(6):402-10.
5. Simultaneous in situ quantification of two cellular lipid pools using orthogonal fluorescent sensors.
Liu SL, Sheng R, O’Connor MJ, Cui Y, Yoon Y, Kurilova S, Lee D*, Cho W*. Angewanthe Chemie International Edition English, 2014, Dec 22;53(52):14387-91.