钟曼丽，博士，讲师。现就职于东北大学生命科学与健康学院神经科学研究所。担任中国神经科学学会成员、辽宁省神经科学学会会员和辽宁省解剖学会会员。承担东北大学生物工程专业和生物制药专业的《解剖与组织胚胎学》，《人体解剖生理学》，《组织学与胚胎学》，《生理学》以及《药理学与生理学实验》5门本科生教学，教学效果获得一系列奖项和好评，作为负责人在学堂在线上开设《生理学》慕课，负责两门本课生混合式教学课程：《生理学》和《人体解剖生理学》。
教育和工作经历
教育经历
2003.09-2008.07 中国医科大学 临床医学 学士
2008.09-2013.07 中国医科大学 人体解剖与组织胚胎学 博士（硕博连读）
国内工作经历
2013.07-至今 东北大学 生命科学与健康学院 讲师
国外工作经历
2019.07-2020.08 美国田纳西大学健康科学中心 国家公派留学 访问学者
主要科研方向
1. 脑锌代谢与学习记忆以及神经退行性疾病发病机理的研究，应用小鼠和细胞模型，探讨金属离子及其转运体调节脑内金属离子代谢的分子机制。
2. 应用相关药物防治神经退行性疾病的发病机理的研究。
主持的基金项目
1. 国家自然科学基金青年科学基金项目（81600941）：虾青素通过调节PPARγ信号通路抑制阿尔茨海默病转基因小鼠脑内Aβ形成的分子机制、17万（直接费用）、结题、2017.01-2019.12、主持。
2. 教育部基本科研业务费“国家项目培育基金”项目（N2120002）：GQ-16通过调节PPARγ信号通路抑制阿尔茨海默病转基因小鼠脑内Aβ形成的分子机制、10万、结题、2021.01-2022.12主持。
3. 教育部基本科研业务费“青年教师科研创新基金”项目（N130320001）：ZnT7基因敲除抑制APP/PS1小鼠脑内老年斑形成和tau蛋白磷酸化的研究、6万、结题、2014.01-2015.12、主持。
4. 教育部基本科研业务费项目（L1520001）：炎症因子调控Aβ产生和脑内沉积的分子机制研究、10万、结题、2015.09-2016.06、主持。
代表性论文
1. Manli Zhong*, Yuhan Wang, Geng Lin, Francesca-Fang Liao, Fu-Ming Zhou*. Dopamine-independent development and maintenance of mouse striatal medium spiny neuron dendritic spines. Neurobiology of Disease. 2023 Jun 1:181:106096. doi: 10.1016/j.nbd.2023.106096. Epub 2023 Mar 29. 影响因子：6.10/Q1
2. Huiling Gao, Hehong Sun, Nan Yan, Pu Zhao, He Xu, Wei Zheng, Xiaoyu Zhang, Tao Wang, Chuang Guo, Manli Zhong*. ATP13A2 Declines Zinc-Induced Accumulation of α-Synuclein in a Parkinson's Disease Model. Int J Mol Sci. 2022 Jul 21;23(14):8035. doi: 10.3390/ijms23148035. 影响因子: 6.90/Q1
3. Manli Zhong, Hejia Kou, Pu Zhao, Wei Zheng, He Xu, Xiaoyu Zhang, Wang Lan, Chuang Guo, Tao Wang, Feng Guo, Zhanyou Wang*, Hui-ling Gao*(共同通讯作者). Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer's Disease Models. Front Aging Neurosci. 2021 Apr 15;13:660249. doi: 10.3389/fnagi.2021.660249. eCollection 2021.影响因子: 5.72/Q1
4. Manli Zhong, Chuang Guo Zhihong Chi, Zhongyan Shan, Weiping Teng, and Zhanyou Wang *.Distribution of zinc and zinc transporters in the mouse ovarian follicles and corpus luteum, Histology and histopathology, 2013,28(11), 1517-1527. 影响因子: 2.13/Q3
5. Manli Zhong, Zhihong Chi, Zhongyan Shan, Weiping Teng, and Zhanyou Wang*. Widespread expression of zinc transporter ZnT (SLC30) family members in mouse endocrine cells, Histochemistry and cell biology, 2012,138(4), 605-616. 影响因子: 2.53/Q2
6. Wei Ma, Manli Zhong, Xiaowu Liu*. Identification of a glycolysis-related lncRNA prognostic signature for clear cell renal cell carcinoma. Bioscience Reports, 2021, 41(8). 影响因子: 3.98/Q3
7. Xiaoyu Zhang, Manli Zhong, Pu Zhao, Xiancheng Zhang, You Li, Xuliang Wang, Jia Sun, Wang Lan, Hehong Sun, Zhanyou Wang*, Hui-ling Gao*. Screening a specific Zn(ii)-binding peptide for improving the cognitive decline of Alzheimer’s disease in APP/PS1 transgenic mice by inhibiting Zn2+-mediated amyloid protein aggregation and neurotoxicity.Biomater Sci. 2019 Nov 19;7(12):5197-5210. doi: 10.1039/c9bm00676a. 影响因子: 7.59/Q1
8. Xiaoyu Zhang, Xiancheng Zhang, Manli Zhong, Pu Zhao, Chuang Guo, You Li, He Xu, Tao Wang, Hui-ling Gao*. A Novel Cu(II)-Binding Peptide Identified by Phage Display Inhibits Cu2+-Mediated Aβ Aggregation. Int J Mol Sci. 2021 Jun 25;22(13):6842. doi: 10.3390/ijms22136842. 影响因子: 6.90/Q1
9. Xiancheng Zhang, Xiaoyu Zhang*, You Li, Manli Zhong, Pu Zhao, Chuang Guo, He Xu, Tao Wang, Hui-ling Gao*. Brain Targeting and Aβ Binding Bifunctional Nanoparticles Inhibit Amyloid Protein Aggregation in APP/PS1 Transgenic Mice. ACS Chem Neurosci. 2021 Jun 16;12(12):2110-2121. doi: 10.1021/acschemneuro.1c00035. Epub 2021 May 27. 影响因子: 5.78/Q1
10. Xiancheng Zhang, Xiaoyu Zhang, Manli Zhong, Pu Zhao, Chuang Guo, You Li, Tao Wang, Hui-ling Gao*. Selection of a d-Enantiomeric Peptide Specifically Binding to PHF6 for Inhibiting Tau Aggregation in Transgenic Mice. ACS Chem Neurosci. 2020 Dec 16;11(24):4240-4253. doi: 10.1021/acschemneuro.0c00518. Epub 2020 Dec 7. 影响因子: 5.78/Q1
11. Cunli Wang, Yiming Yang, Xiaoyu Zhang, Zhenqiang Shi, Huiling Gao, Manli Zhong, Yonggang Fan, Hongyan Zhang, Bo Liu, Guangyan Qing. 5Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer's disease. Sci Adv.2023 May 26;9(21):eade0293. doi: 10.1126/sciadv.ade0293. Epub 2023 May 26. 影响因子: 13.12/Q1
12. Ying-Ying Yang, Yan-Tao Ren, Meng-Yu Jia, Chen-Yang Bai, Xiu-Ting Liang, Hui-Ling Gao, Man-Li Zhong, Tao Wang , Chuang Guo*. The human islet amyloid polypeptide reduces hippocampal tauopathy and behavioral impairments in P301S mice without inducing neurotoxicity or seeding amyloid aggregation. Exp Neurol. 2023 Apr:362:114346. doi: 10.1016/j.expneurol.2023.114346. Epub 2023 Feb 5. 影响因子: 5.62/Q2
13. Linbo Li, Yonggang Fan, Wenxi Wu, Chenyang Bai, Mengyu Jia, Jiangping Hu, Hui-ling Gao, Tao Wang, Manli Zhong, Xueshi Huang, Chuang Guo*. Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer's disease. Bioorg Chem. 2022 Aug 17;128:106100.影响因子: 5.31/Q1
14. Xue Wang, Huiling Gao, Xiaoyu Zhang, Shengxu Qian, Cunli Wang, Lijing Deng, Manli Zhong, Guangyan Qing *.Aspartic Acid-Modified Phospholipids Regulate Cell Response and Rescue Memory Deficits in APP/PS1 Transgenic Mice. ACS Chem Neurosci. 2022 Jul 20;13(14):2154-2163. 影响: 5.78/Q1
15. Hailong Li, Yanjian Li, Tianshu Sun, Wei Du, Chao Li, Chenhao Suo, Yang Meng, Qiaojing Liang, Tian Lan, Manli Zhong, Sheng Yang, Cheng Niu, Dancheng Li, Chen Ding*. Unveil the transcriptional landscape at the Cryptococcus-host axis in mice and nonhuman primates. PLoS Negl Trop Dis. 2019 Jul 22;13(7):e0007566.影响因子: 4.78/Q1
16. Yanjian Li #, Hailong Li #, Mingfei Sui, Minghui Li, Jiamei Wang, Yang Meng, Tianshu Sun, Qiaojing Liang, Chenhao Suo, Xindi Gao, Chao Li, Zhuoran Li, Wei Du, Baihua Zhang, Sixiang Sai, Zhang Zhang, Jing Ye, Hongchen Wang, Shang Yue, Jiayi Li, Manli Zhong, Changbin Chen, Shouliang Qi, Ling Lu, Dancheng Li, Chen Ding*. Fungal acetylome comparative analysis identifies an essential role of acetylation in human fungal pathogen virulence. Commun Biol. 2019 May 1;2:154. doi: 10.1038/s42003-019-0419-1.影响因子: 6.55/Q1
17. Zhuo Wang, Ya-Hong Zhang, Wei Zhang, Hui-Ling Gao, Man-Li Zhong, Ting-Ting Huang, Rui-Fang Guo, Na-Na Liu, Dan-Dan Li, Yin Li, Zhan-You Wang, Pu Zhao*. Copper chelators promote nonamyloidogenic processing of AβPP via MT1/2 /CREB-dependent signaling pathways in AβPP/PS1 transgenic mice. J Pineal Res. 2018 Apr 30. [Epub ahead of print] 影响因子: 12.08/Q1
18. Zhuo Wang, Ya-Hong Zhang, Chuang Guo, Hui-Ling Gao, Man-Li Zhong, Ting-Ting Huang, Na-Na Liu, Rui-Fang Guo, Tian Lan, Wei Zhang, Zhan-You Wang, Pu Zhao*. Tetrathiomolybdate Treatment Leads to the Suppression of Inflammatory Responses through the TRAF6/NFκB Pathway in LPS-Stimulated BV-2 Microglia. Front Aging Neurosci, 2018 Feb 27;10:9.影响因子: 5.72/Q1
19. Chuang Guo, Li-Juan Hao, Zhao-Hui Yang, Rui Chai, Shuai Zhang, Yu Gu, Hui-Ling Gao, Man-Li Zhong, Tao Wang, Jia-Yi Li, Zhan-You Wang*. Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice. Exp Neurol. 2016, 280, 13-23.影响因子: 5.62/Q2
20. Chuang Guo*, Yu-Xin Zhang, Tao Wang, Man-Li Zhong, Zhao-Hui Yang, Li-Juan Hao, Rui Chai, Shuai Zhang. Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice. Front Aging Neurosci, 2015, 7, 104.影响因子: 5.72/Q1
21. Chuang Guo, Pu Wang, Man-Li Zhong, Tao Wang, Xue-Shi Huang, Jia-Yi Li, Zhan-You Wang*. Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain. Neurochemistry international, 2013,62(2), 165-172. 影响因子: 4.30/Q2
联系方式
地址：辽宁省沈阳市浑南区创新路195号，东北大学生命科学与健康学院神经科学研究所。
E-mail：zhongmanli@mail.neu.edu.cn，zhongmanli_cmu@hotmail.com
邮编：110169
